The fuel economy in the 2021 Lexus RX 350 near Hanover, PA, is much lower than that of the 2021 Audi Q5. The 2021 RX 350 also doesn't have all-wheel drive as a standard feature, which is standard in the 2021 Q5. To get all-wheel drive, you'll need to spend significantly more to get this option equipped, while the 2021 Q5 can give you the Audi-exclusive quattro all-wheel drive. Drivers who want a one-of-a-kind look can find it in the 2021 Audi Q5. With the 2021 Lexus RX 350, this is an economy model remade into the luxury lineup, so you won't be getting such an iconic look as the 2021 Q5 can offer. Part of the reason you choose an SUV is to get more space. The 2021 Audi Q5 can offer between 25.1 cubic feet and 53.1 cubic feet of cargo space. With the 2021 Lexus RX 350, your cargo space ranges from 16 cubic feet and 32.6 cubic feet of cargo space.